Carrimycin in a Patient with Acute Myeloid Leukemia Complicated with Life-Threatening Mixed Perianal Infection: A Case Report and Literature Review

Xiawan Yang; Yingying Shen; Tonglin Hu; Hangchao Li; Yun Zhang; Yiping Shen; Dijiong Wu

doi:10.2147/IDR.S475982

Carrimycin in a Patient with Acute Myeloid Leukemia Complicated with Life-Threatening Mixed Perianal Infection: A Case Report and Literature Review

Infect Drug Resist. 2024 Aug 21:17:3637-3642. doi: 10.2147/IDR.S475982. eCollection 2024.

Authors

Xiawan Yang^#^{1

2

3}, Yingying Shen^#^{1

2

3}, Tonglin Hu^{1

2

3}, Hangchao Li^{1

2

3}, Yun Zhang^{1

2

3}, Yiping Shen^{1

2

3}, Dijiong Wu^{1

2

3

4}

Affiliations

¹ Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, People's Republic of China.
² The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China.
³ National Traditional Chinese Medicine Clinical Research Base (Hematology), Hangzhou, Zhejiang, People's Republic of China.
⁴ Department of Oncology and Hematology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Zhejiang Chinese Medicine University, Wenzhou, Zhejiang, People's Republic of China.

^# Contributed equally.

Abstract

Background: Perianal infection has a high incidence and mortality rate in patients with acute myeloid leukemia (AML). Sometimes there is a lack of effective anti-infective treatment regimens.

Case presentation: A 58-year-old male diagnosed with AML presented with secondary perianal infection and septic shock upon admission. Although multiple pathogen cultivation and antibiotic sensitivity tests indicated the presence of sensitive strains, the corresponding antibiotics were ineffective. As a last resort, carrimycin was introduced, ultimately controlling the infection and leading to disease remission.

Conclusion: Carrimycin is a complementary treatment option when conventional antibiotic therapy fails. It operates through multiple mechanisms beyond its antibiotic properties and warrants further investigation.

Keywords: acute myeloid leukemia; carrimycin; immunomodulatory; perianal infection.

Publication types

Case Reports

Grants and funding

The present study was supported by the Zhejiang Provincial Natural Science Foundation (No. LY21H290003), National Natural Science Foundation of China (No. 81503296), Zhejiang Scientific Research Fund of Traditional Chinese Medicine (NO. 2020ZB085 and No.2021ZQ029), Specific Program of Scientific Research of Zhejiang Chinese Medicine University for Affiliated Hospital (NO.2023FSYYZZ04), Project of Academic Inheritance Studio of Famous and Aged Chinese Medicine Experts in Zhejiang Province (No. GZS2021022).