Alzheimer's and metabolism wed with IDO1

Science. 2024 Aug 23;385(6711):826-827. doi: 10.1126/science.adr5836. Epub 2024 Aug 22.

Abstract

Kynurenine pathway inhibition reverses deficits in Alzheimer's mouse models.

Publication types

  • News
  • Comment

MeSH terms

  • Alzheimer Disease* / drug therapy
  • Alzheimer Disease* / metabolism
  • Amyloid beta-Peptides / metabolism
  • Animals
  • Disease Models, Animal
  • Humans
  • Indoleamine-Pyrrole 2,3,-Dioxygenase* / metabolism
  • Kynurenine* / metabolism
  • Mice
  • Tryptophan / metabolism

Substances

  • Amyloid beta-Peptides
  • IDO1 protein, mouse
  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Kynurenine
  • Tryptophan