Rapid campimetry - a novel robust kinetic approach for visual field screening in glaucoma

Khaldoon O Al-Nosairy; Katharina Rodenbeck; Sophie Vorholt; Nidele Djouoma; Hagen Thieme; Fabian Müller; Michael B Hoffmann

doi:10.3389/fmed.2024.1419147

Rapid campimetry - a novel robust kinetic approach for visual field screening in glaucoma

Front Med (Lausanne). 2024 Aug 2:11:1419147. doi: 10.3389/fmed.2024.1419147. eCollection 2024.

Authors

Khaldoon O Al-Nosairy¹, Katharina Rodenbeck^{1

2}, Sophie Vorholt¹, Nidele Djouoma¹, Hagen Thieme¹, Fabian Müller³, Michael B Hoffmann^{1

4}

Affiliations

¹ Department of Ophthalmology, Faculty of Medicine, Otto-von-Guericke University, Magdeburg, Germany.
² Department of Optometry, Berlin University of Applied Sciences and Technology, Berlin, Germany.
³ H & M Medical Solutions GmbH, Berlin, Germany.
⁴ Center for Behavioral Brain Sciences, Magdeburg, Germany.

Abstract

Purpose: To investigate the robustness and variability of a novel kinetic visual field (VF) screening method termed rapid campimetry (RC).

Methods: In RC visual field (VF) screening is enabled via kinetic-based testing on any computer (10°/4.7 s at 40-cm viewing distance) and high contrast in a dark room (1 cd/cm²). In experiment (1): 30 participants [20 healthy participants (HC), 5 glaucoma patients (GLA) and 5 patients with cataract (CAT)] were included to test the intra-session variability (fatigue effect) and the following effects on RC: room illumination (140 cd/m²), ±3 D refractive errors, media opacity. In experiment (2): Inter-session variability (1-3 weeks apart) was assessed in 10 HC and 10 GLA. Since RC detects absolute scotomas, the outcome measure was the size of physiological (blindspot) and pathological (glaucoma) scotomas in degrees. A repeated measures ANOVA was employed in experiment 1 and intraclass correlation (ICC) in experiment 2.

Results: Neither the size of the blindspot nor the VF defects differed significantly between the different testing conditions. For intra-session variability, the average bias of blindspot size was -0.6 ± 2.5°, limits of agreement (LOA), in comparison to 0.3 ± 1.5° for VF defects, both with ICC of 0.86 and 0.93, respectively. For the inter-session repeatability, the average bias and LOA for blindspot size was 0.2 ± 3.85° in comparison 1.6 ± 3.1° for VF defects, both with ICC of 0.87 and 0.91, respectively.

Conclusion: RC was robust to suboptimal testing VF conditions and showed good-to-excellent reliability between VF testing visits holding high potential for teleophthalmology.

Keywords: confounding VF factors; glaucoma; rapid campimetry; teleophthalmology; visual field.

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of the article. This work was supported by funding of the German Research Foundation (DFG, HO2002/20-1) to MBH.