Collagen VIII in vascular diseases

Qian Li; Yin Tintut; Linda L Demer; Roberto I Vazquez-Padron; Michelle P Bendeck; Jeffrey J Hsu

doi:10.1016/j.matbio.2024.08.006

Collagen VIII in vascular diseases

Matrix Biol. 2024 Nov:133:64-76. doi: 10.1016/j.matbio.2024.08.006. Epub 2024 Aug 16.

Authors

Qian Li¹, Yin Tintut², Linda L Demer³, Roberto I Vazquez-Padron⁴, Michelle P Bendeck⁵, Jeffrey J Hsu⁶

Affiliations

¹ Departments of Physiology, Bioengineering University of California, Los Angeles, Los Angeles, California, USA.
² Departments of Physiology, Bioengineering University of California, Los Angeles, Los Angeles, California, USA; Departments of Medicine, Bioengineering University of California, Los Angeles, Los Angeles, California, USA; Departments of Orthopedic Surgery, Bioengineering University of California, Los Angeles, Los Angeles, California, USA.
³ Departments of Physiology, Bioengineering University of California, Los Angeles, Los Angeles, California, USA; Departments of Medicine, Bioengineering University of California, Los Angeles, Los Angeles, California, USA; Bioengineering University of California, Los Angeles, Los Angeles, California, USA.
⁴ Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, USA; Bruce W. Carter Veteran Affairs Medical Center, Miami, Florida, USA.
⁵ Departments of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada; Ted Rogers Heart Research Centre, University of Toronto, Toronto, Ontario, Canada.
⁶ Departments of Physiology, Bioengineering University of California, Los Angeles, Los Angeles, California, USA; Bioengineering University of California, Los Angeles, Los Angeles, California, USA; Veterans Affairs Greater Los Angeles Health Care System, Los Angeles, California, USA. Electronic address: jjhsu@mednet.ucla.edu.

Abstract

Collagens have dual functions in the extracellular matrix (ECM), acting as both structural components and signaling molecules in matricellular communication. Although collagen molecules share a common triple helix motif, the supramolecular organization helps classify them into nearly 30 different types of collagens. Collagen type VIII is a non-fibrillar, short-chain, network-forming collagen that is expressed throughout the vasculature. Collagen VIII expression is aberrant in cardiovascular, lung, and renal disease, as well as in several different types of cancer. It plays active roles in angiogenesis, vessel injury repair, maintenance of arterial compliance, atherosclerotic plaque formation and stability modulation, fibrosis, and ECM remodeling. This review presents an overview of the characteristics of collagen VIII in vascular-related disorders, from clinical significance to laboratory studies, with a major focus on highlighting the signaling properties of collagen VIII in the vascular ECM. The expression patterns of collagen VIII in human diseases and experimental animal models highlight the protein's important yet underexplored functions. A deeper understanding of its mechanisms and downstream signaling pathways may pave the way for translational and tissue engineering applications of collagen VIII.

Keywords: Angiogenesis; COL8A1; Collagen VIII; Collagen type VIII; Extracellular matrix; Vascular disease; Vascular remodeling.

Publication types

Review

MeSH terms

Animals
Collagen Type VIII* / genetics
Collagen Type VIII* / metabolism
Extracellular Matrix* / metabolism
Humans
Signal Transduction*
Vascular Diseases* / genetics
Vascular Diseases* / metabolism
Vascular Diseases* / pathology

Substances

Collagen Type VIII

Abstract

Publication types

MeSH terms

Substances

Grants and funding