An effective procedure used metal-organic framework for determination of cadmium ions in real tap water and human blood plasma samples

Abstract

A newly developed 2H5MA-MOF sensor by covalently linking NH₂-MIL-53(Al) with 2'-Hydroxy-5'-methylacetophenon, designed for highly sensitive and selective detection of Cd²⁺ ions using fluorometric methods. Detailed structural and morphological analyses confirmed the sensor's unique properties. It demonstrated an impressive linear detection range from 0 to 2 ppm, with an exceptionally low detection limit of 5.77 × 10^-2 ppm and a quantification limit of 1.75 × 10^-1 ppm, indicating its high sensitivity (R² = 0.9996). The sensor also responded quickly, detecting Cd²⁺ within just 30 s at pH 4. We successfully tested it on real samples of tap water and human blood plasma, achieving recovery rates between 96 % and 104 %. The accuracy of these findings was further validated by comparison with ICP-OES. Overall, the 2H5MA-MOF sensor shows great potential for fast, ultra-sensitive, and reliable detection of Cd²⁺ ions, making it a promising tool for environmental and biomedical applications.

Keywords: Cd(2+) ion detection; Fluorometric sensor; Metal organic framework; NH(2)-MIL-53(Al); Water sample.