Identification of 43 novel HLA alleles by PacBio single molecule real-time sequencing in haematopoietic cell donors

HLA. 2024 Aug;104(2):e15645. doi: 10.1111/tan.15645.

Authors

Albert J E French¹, Jonathan A M Lucas^{1

2}, Michael A Cooper¹, Steven G E Marsh^{1

2}, Neema P Mayor^{1

2}

Affiliations

¹ Anthony Nolan Research Institute, Royal Free Hospital, London, UK.
² UCL Cancer Institute, Royal Free Campus, London, UK.

PMID: 39148299
DOI: 10.1111/tan.15645

Abstract

A total of 43 novel HLA alleles detected in haematopoietic cell donors using single molecule real-time DNA sequencing.

Keywords: HCT; HLA; SMRT sequencing; non‐coding polymorphism; novel allele.

© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Alleles*
HLA Antigens* / genetics
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells / metabolism
High-Throughput Nucleotide Sequencing / methods
Histocompatibility Testing* / methods
Humans
Sequence Analysis, DNA / methods
Tissue Donors*

Substances

HLA Antigens

Grants and funding

803716/Anthony Nolan