Invasive Coronary Physiology in Heart Transplant Recipients: State-of-the-Art Review

Negeen Shahandeh; Justin Song; Kan Saito; Yasuhiro Honda; Frederik M Zimmermann; Jung-Min Ahn; William F Fearon; Rushi V Parikh

doi:10.1016/j.jscai.2023.100627

Invasive Coronary Physiology in Heart Transplant Recipients: State-of-the-Art Review

J Soc Cardiovasc Angiogr Interv. 2023 Mar 21;2(3):100627. doi: 10.1016/j.jscai.2023.100627. eCollection 2023 May-Jun.

Authors

Negeen Shahandeh¹, Justin Song¹, Kan Saito², Yasuhiro Honda², Frederik M Zimmermann³, Jung-Min Ahn⁴, William F Fearon⁵, Rushi V Parikh¹

Affiliations

¹ Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, California.
² Division of Cardiovascular Medicine, Stanford University, Stanford, California.
³ Catharina Hospital, Eindhoven, the Netherlands.
⁴ Department of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
⁵ Division of Cardiovascular Medicine, Stanford University and VA Palo Alto Health Care Systems, Stanford, California.

Abstract

Cardiac allograft vasculopathy is a leading cause of allograft failure and death among heart transplant recipients. Routine coronary angiography and intravascular ultrasound in the early posttransplant period are widely accepted as the current standard-of-care diagnostic modalities. However, many studies have now demonstrated that invasive coronary physiological assessment provides complementary long-term prognostic data and helps identify patients who are at risk of accelerated cardiac allograft vasculopathy and acute rejection.

Keywords: cardiac allograft vasculopathy; coronary flow reserve; coronary physiology; fractional flow reserve; heart transplantation; index of microcirculatory resistance.

Publication types

Review