Direct toll-like receptor triggering in colorectal cancer-associated stromal cells elicits immunostimulatory properties leading to enhanced immune cell recruitment

Gut. 2025 Jan 17;74(2):333-335. doi: 10.1136/gutjnl-2023-331759.

Julija Djordjevic^{1

2}, Nubia Sarahi Cisneros Romero^{3

4}, Luciano Cascione^{2

5}, Valentina Mele⁴, Eleonora Cremonesi⁴, Elisa Sorrenti^{1

2}, Camilla Basso^{1

2}, Martina Villa¹, Agnese Cianfarani^{1

6}, Raffaello Roesel^{2

6}, Jacopo Galafassi⁶, Pietro Edoardo Majno-Hurst^{2

6}, Giulio Spagnoli⁷, Dimitrios Christoforidis^{2

6}, Giandomenica Iezzi^{8

2}

¹ Laboratory for Surgical Research, EOC Laboratories for Translational Research, Bellinzona, Switzerland.
² Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland.
³ Faculty of Natural Sciences, University of Basel, Basel, Switzerland.
⁴ Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
⁵ Bioinformatics Core Unit, Institute of Oncology Research (IOR), Bellinzona, Switzerland.
⁶ Department of Surgery, Ente Ospedaliero Cantonale (EOC), Bellinzona, Switzerland.
⁷ Institute of Translational Pharmacology, National Research Council, Roma, Italy.
⁸ Laboratory for Surgical Research, EOC Laboratories for Translational Research, Bellinzona, Switzerland giandomenica.iezzi@eoc.ch.

No abstract available

Keywords: CHEMOKINES; COLORECTAL CANCER; IMMUNE RESPONSE; INTESTINAL BACTERIA; MYOFIBROBLASTS.

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