Managing surgical relapse risk in acquired thrombotic thrombocytopenic purpura: a systematic review

Morgana Pinheiro Maux Lessa; Alexandre Soares Ferreira Junior; Margaret Graton; Erin Simon; Leila Ledbetter; Oluwatoyosi A Onwuemene

doi:10.1016/j.rpth.2024.102478

Managing surgical relapse risk in acquired thrombotic thrombocytopenic purpura: a systematic review

Res Pract Thromb Haemost. 2024 Jun 19;8(5):102478. doi: 10.1016/j.rpth.2024.102478. eCollection 2024 Jul.

Authors

Morgana Pinheiro Maux Lessa¹, Alexandre Soares Ferreira Junior^{1

2}, Margaret Graton³, Erin Simon³, Leila Ledbetter³, Oluwatoyosi A Onwuemene⁴

Affiliations

¹ Department of Medicine, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, São Paulo, Brazil.
² General and Applied Biology Program, Institute of Biosciences (IBB), Sao Paulo State University (UNESP), Botucatu, Brazil.
³ Duke University Medical Center Library, Durham, North Carolina, USA.
⁴ Division of Hematology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.

Abstract

•Thrombotic thrombocytopenic purpura (TTP) may relapse after surgery.•In a systematic review, we assessed preoperative TTP prophylaxis.•Pre-emptive ADAMTS-13 activity measurement prior to surgery may improve relapse risk.•Preoperative TTP prophylaxis may lower surgical relapse risk.

Keywords: precipitating factors; relapse; surgery; surgical procedures; thrombotic thrombocytopenic purpura.