Exploring Uncommon Neurologic Complication in Young Diabetics with Osmotic Demyelination Syndrome: A Case Series and Literature Review

Manisha Gupta; Ramesh Gurjar; Arpit Agrawal; Abhijeet Kumar Kohat; Abhishek Kumar

doi:10.4103/aian.aian_390_24

Exploring Uncommon Neurologic Complication in Young Diabetics with Osmotic Demyelination Syndrome: A Case Series and Literature Review

Ann Indian Acad Neurol. 2024 Aug 8. doi: 10.4103/aian.aian_390_24. Online ahead of print.

Authors

Manisha Gupta¹, Ramesh Gurjar², Arpit Agrawal¹, Abhijeet Kumar Kohat¹, Abhishek Kumar³

Affiliations

¹ Department of Neurology, Dau Kalyan Singh Post Graduate Institute and Research Centre, Raipur, Chattisgarh, India.
² Department of Medicine, Pandit Jawahat Lal Nehru Memorial Medical College, Raipur, Chattisgarh, India.
³ Department of Cardiology, All India Institute of Medical Sciences, Raipur, Chattisgarh, India.

PMID: 39113377
DOI: 10.4103/aian.aian_390_24

Abstract

Osmotic demyelination syndrome (ODS) is well known to be associated with the rapid correction of hyponatremia. However, there is limited literature on its link to persistent or corrected hyperglycemic states in diabetic patients. We report two young patients with ODS and hyperglycemia. Neuroimaging and blood tests indicated central pontine and extrapontine myelinolysis with a hyperglycemic hyperosmolar state (HHS). These unusual cases provide insight into the neurologic complications of hyperglycemia.