Computational investigation of stochastic Zika virus optimal control model using Legendre spectral method

Sci Rep. 2024 Aug 5;14(1):18112. doi: 10.1038/s41598-024-69096-x.

Abstract

This study presents a computational investigation of a stochastic Zika virus along with optimal control model using the Legendre spectral collocation method (LSCM). By accumulation of stochasticity into the model through the proposed stochastic differential equations, we appropriating the random fluctuations essential in the progression and disease transmission. The stability, convergence and accuracy properties of the LSCM are conscientiously analyzed and also demonstrating its strength for solving the complex epidemiological models. Moreover, the study evaluates the various control strategies, such as treatment, prevention and treatment pesticide control, and identifies optimal combinations that the intervention costs and also minimize the proposed infection rates. The basic properties of the given model, such as the reproduction number, were determined with and without the presence of the control strategies. For R 0 < 0 , the model satisfies the disease-free equilibrium, in this case the disease die out after some time, while for R 0 > 1 , then endemic equilibrium is satisfied, in this case the disease spread in the population at higher scale. The fundamental findings acknowledge the significant impact of stochastic phonemes on the robustness and effectiveness of control strategies that accelerating the need for cost-effective and multi-faceted approaches. In last the results provide the valuable insights for public health department to enabling more impressive mitigation of Zika virus outbreaks and management in real-world scenarios.

Keywords: Brownian motion; Control variables; Legendre polynomials; Legendre spectral collocation method; Reproduction number; Stochastic asymptotic stability; Zika virus model.

MeSH terms

  • Computer Simulation
  • Epidemiological Models
  • Humans
  • Stochastic Processes*
  • Zika Virus Infection* / epidemiology
  • Zika Virus Infection* / prevention & control
  • Zika Virus Infection* / transmission
  • Zika Virus* / physiology