[Do not overuse doxycycline as prophylaxis for uncomplicated sexually transmitted infections]

Finn Filén; Jaran Eriksen; Catharina Missailidis

[Do not overuse doxycycline as prophylaxis for uncomplicated sexually transmitted infections]

Lakartidningen. 2024 Aug 2:121:24036.

[Article in Swedish]

Authors

Finn Filén¹, Jaran Eriksen², Catharina Missailidis³

Affiliations

¹ överläkare, infektionssjukdomar och dermatovenereologi, Venhälsan, infektionskliniken, Södersjukhuset.
² docent, specialistläkare, infektionssjukdomar och klinisk farmakologi, Venhälsan, infektionskliniken, Södersjukhuset.
³ med dr, överläkare, infektionssjukdomar, medicinskt ledningsansvarig läkare, Venhälsan, infektionskliniken, Södersjukhuset.

PMID: 39101261

Abstract

STI prophylaxis using doxycycline is discussed internationally for persons at high risk of STIs (Doxy-PEP). Doxy-PEP would probably have limited effect on gonorrhoea due to resistance to tetracyclines. Doxy-PEP may reduce the incidence of chlamydia and syphilis, but would not reduce the number of complicated infections. Further studies are needed on the effects of intermittent antibiotic use on the microbiome or antibiotic resistance in general.

Publication types

English Abstract

MeSH terms

Anti-Bacterial Agents* / administration & dosage
Anti-Bacterial Agents* / adverse effects
Anti-Bacterial Agents* / therapeutic use
Antibiotic Prophylaxis
Chlamydia Infections* / drug therapy
Chlamydia Infections* / prevention & control
Doxycycline* / administration & dosage
Doxycycline* / therapeutic use
Drug Resistance, Bacterial
Gonorrhea* / drug therapy
Gonorrhea* / prevention & control
Humans
Sexually Transmitted Diseases* / prevention & control
Syphilis / drug therapy
Syphilis / prevention & control

Substances

Doxycycline
Anti-Bacterial Agents