Long-Term Outcomes Following Hypoxic Ischemic Encephalopathy

Simone L Huntingford; Stephanie M Boyd; Sarah J McIntyre; Shona C Goldsmith; Rod W Hunt; Nadia Badawi

doi:10.1016/j.clp.2024.04.008

Long-Term Outcomes Following Hypoxic Ischemic Encephalopathy

Clin Perinatol. 2024 Sep;51(3):683-709. doi: 10.1016/j.clp.2024.04.008. Epub 2024 May 28.

Authors

Simone L Huntingford¹, Stephanie M Boyd², Sarah J McIntyre³, Shona C Goldsmith³, Rod W Hunt⁴, Nadia Badawi⁵

Affiliations

¹ Department of Paediatrics, Monash University, 246 Clayton Road, Clayton, Victoria 3168, Australia; Monash Newborn, Monash Health, 246 Clayton Road, Clayton, Victoria 3168, Australia; Paediatric Infant Perinatal Emergency Retrieval, Royal Children's Hospital, 50 Flemington Road, Parkville, Victoria 3052, Australia. Electronic address: Simone.huntingford@monashhealth.org.
² Grace Centre for Newborn Intensive Care, The Children's Hospital at Westmead, Hawkesbury Road, Westmead, New South Wales 2145, Australia; Faculty of Medicine and Health, University of Sydney, Campderdown, New South Wales 2006, Australia.
³ CP Alliance Research Institute, Specialty of Child and Adolescent Health, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
⁴ Department of Paediatrics, Monash University, 246 Clayton Road, Clayton, Victoria 3168, Australia; Monash Newborn, Monash Health, 246 Clayton Road, Clayton, Victoria 3168, Australia; CP Alliance Research Institute, Specialty of Child and Adolescent Health, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
⁵ Grace Centre for Newborn Intensive Care, The Children's Hospital at Westmead, Hawkesbury Road, Westmead, New South Wales 2145, Australia; CP Alliance Research Institute, Specialty of Child and Adolescent Health, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.

PMID: 39095104
DOI: 10.1016/j.clp.2024.04.008

Abstract

Hypoxic ischemic encephalopathy (HIE) is the most common cause of neonatal encephalopathy and results in significant morbidity and mortality. Long-term outcomes of the condition encompass impairments across all developmental domains. While therapeutic hypothermia (TH) has improved outcomes for term and late preterm infants with moderate to severe HIE, trials are ongoing to investigate the use of TH for infants with mild or preterm HIE. There is no evidence that adjuvant therapies in combination with TH improve long-term outcomes. Numerous trials of various adjuvant therapies are underway in the quest to further improve outcomes for infants with HIE.

Keywords: Cerebral palsy (CP); Cognition; Hypoxic ischemic encephalopathy (HIE); Long-term; Neonatal; Neurodevelopmental (ND) outcome; Therapeutic hypothermia (TH).

Publication types

Review

MeSH terms

Humans
Hypothermia, Induced* / methods
Hypoxia-Ischemia, Brain* / therapy
Infant, Newborn
Infant, Premature*
Treatment Outcome