Abstract
In an experimental model of Alzheimer's disease in mice, oral administration of trehalose disaccharide reduces neuroinflammation assessed by the expression level of microglia activation marker Iba1 and affects the neutrophil degranulation activity. A potential anti-inflammatory effect of 4% trehalose solution associated with a decrease in the activity of leukocyte elastase in plasma was revealed.
Keywords:
Alzheimer’s disease; experimental model; leukocyte elastase; microglia; trehalose.
© 2024. Springer Science+Business Media, LLC, part of Springer Nature.
MeSH terms
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Alzheimer Disease* / drug therapy
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Alzheimer Disease* / metabolism
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Alzheimer Disease* / pathology
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Animals
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Anti-Inflammatory Agents / pharmacology
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Calcium-Binding Proteins / metabolism
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Disaccharides / pharmacology
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Disease Models, Animal*
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Inflammation / drug therapy
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Inflammation / metabolism
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Leukocyte Elastase / metabolism
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Male
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Mice
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Microfilament Proteins / metabolism
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Microglia* / drug effects
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Microglia* / metabolism
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Neutrophils / drug effects
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Neutrophils / metabolism
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Trehalose* / pharmacology
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Trehalose* / therapeutic use
Substances
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Trehalose
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Microfilament Proteins
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Calcium-Binding Proteins
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Leukocyte Elastase
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Aif1 protein, mouse
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Disaccharides
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Anti-Inflammatory Agents