Rhodium(I)-Catalyzed Cascade Annulation of 1, n-Diynyl Nitrones to 3,4-Fused Fully Substituted Furans

Xiangdong Yu; Xiaowen Ji; Dandan Shang; Lei Yu; Philip Wai Hong Chan; Weidong Rao

doi:10.1021/acs.orglett.4c02287

Rhodium(I)-Catalyzed Cascade Annulation of 1, n-Diynyl Nitrones to 3,4-Fused Fully Substituted Furans

Org Lett. 2024 Aug 9;26(31):6631-6636. doi: 10.1021/acs.orglett.4c02287. Epub 2024 Aug 1.

Authors

Xiangdong Yu¹, Xiaowen Ji¹, Dandan Shang¹, Lei Yu², Philip Wai Hong Chan², Weidong Rao¹

Affiliations

¹ Jiangsu Co-Innovation Center for Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
² School of Chemistry, Monash University, Clayton, Victoria 3800, Australia.

PMID: 39087730
DOI: 10.1021/acs.orglett.4c02287

Abstract

A method for the assembly of fully substituted furans containing a 3,4-fused 5-8-membered carbocycle, heterocycle, or spirocycle from rhodium(I)-catalyzed and 1,1,1,3,3,3-hexafluoroisopropanol (HFIP)-assisted cascade annulation of 1,n-diynyl nitrones has been developed.