Identification of a new flavonol glucuronide from Alpinia oxyphylla

Jiao Zhao; Dawei Ji; Qiang Chen; Mengzhu Dai; Qun Wang; Hongtao Xu; Cong Ma

doi:10.1080/14786419.2024.2386129

Identification of a new flavonol glucuronide from Alpinia oxyphylla

Nat Prod Res. 2024 Jul 30:1-4. doi: 10.1080/14786419.2024.2386129. Online ahead of print.

Authors

Jiao Zhao¹, Dawei Ji², Qiang Chen³, Mengzhu Dai⁴, Qun Wang⁵, Hongtao Xu⁶, Cong Ma⁷

Affiliations

¹ Department of Gynecology, Liaoning Cancer Hospital & Institute, Cancer Hospital of China Medical University, Cancer Hospital of Dalian University of Technology, Shenyang, China.
² Department of General Surgery, The Fourth People's Hospital of Shenyang, Shenyang, China.
³ Marxist Academy, Liaoning University of Traditional Chinese Medicine, Shenyang, China.
⁴ Graduate School, Liaoning University of Traditional Chinese Medicine, Shenyang, China.
⁵ Key Lab of MoE for TCM Viscera-State Theory & Apps, Liaoning University of Traditional Chinese Medicine, Shenyang, China.
⁶ Department of Anesthesiology, Liaoning Cancer Hospital & Institute, Cancer Hospital of China Medical University, Cancer Hospital of Dalian University of Technology, Shenyang, China.
⁷ First Clinical College, Liaoning University of Traditional Chinese Medicine, Shenyang, China.

PMID: 39078886
DOI: 10.1080/14786419.2024.2386129

Abstract

The fruits of Alpinia oxyphylla has been used a famous traditional Chinese medicine. A chemical investigation on the fruits of A. oxyphylla resulted in the isolation of one new acetylated flavanol glucuronide (1) and two known compounds (2-3). Compound 1 displayed a weak inhibitory effect on U251 cells with the IC₅₀ value 128.51 μM while the positive control drug temozolomide exhibited the IC₅₀ value 35.37 μM.

Keywords: Flavonoid glycoside; NMR; U251.