Effectiveness of desensitizing toothpastes in reducing tooth sensitivity after tooth bleaching: a systematic review

Clin Oral Investig. 2024 Jul 30;28(8):457. doi: 10.1007/s00784-024-05857-2.

Abstract

Objective: To evaluate the effectiveness of desensitizing toothpastes in reducing post-bleaching tooth sensitivity.

Materials and methods: A systematic review of randomized clinical trials was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. Electronic searches were conducted in the PubMed/MEDLINE, Scopus, Web of Science, The Cochrane Library and Embase databases, using the following terms: (dentifrices OR toothpaste) AND (sensitive OR sensitivity OR dental sensitivity) AND (dental bleaching OR tooth bleaching OR dental whitening OR tooth whitening).

Results: Five studies involving 387 individuals undergoing in-office or at-home teeth bleaching were reviewed. Desensitizing toothpastes reduced sensitivity effectively after home bleaching with 22% carbamide peroxide and single-session in-office bleaching with 35% hydrogen peroxide. However, they were ineffective for home bleaching with 16% carbamide peroxide and in-office bleaching across two sessions with 35% or 38% hydrogen peroxide.

Conclusion: Desensitizing toothpastes are effective for home bleaching with high concentration carbamide peroxide and single-session in-office bleaching with highly concentrated hydrogen peroxide, but ineffective for home bleaching with low concentration carbamide peroxide and two-session in-office bleaching with concentrated hydrogen peroxide.

Keywords: Sensitivity; Tooth whitening; Toothpastes.

Publication types

  • Systematic Review
  • Review

MeSH terms

  • Carbamide Peroxide*
  • Dentin Desensitizing Agents* / therapeutic use
  • Dentin Sensitivity* / drug therapy
  • Dentin Sensitivity* / prevention & control
  • Humans
  • Hydrogen Peroxide*
  • Peroxides / pharmacology
  • Tooth Bleaching Agents*
  • Tooth Bleaching* / methods
  • Toothpastes*
  • Urea / analogs & derivatives
  • Urea / pharmacology
  • Urea / therapeutic use

Substances

  • Toothpastes
  • Tooth Bleaching Agents
  • Dentin Desensitizing Agents
  • Carbamide Peroxide
  • Hydrogen Peroxide
  • Urea
  • Peroxides