The Role of Lipid Subcomponents in the Development of Atherosclerotic Plaques

Lei Nie; Xuying Xiang; Cheng Wen; Feng Zhang; Yuanpeng Xia; Yong Wang; Ling Mao

doi:10.31083/j.rcm2405139

The Role of Lipid Subcomponents in the Development of Atherosclerotic Plaques

Rev Cardiovasc Med. 2023 May 5;24(5):139. doi: 10.31083/j.rcm2405139. eCollection 2023 May.

Authors

Lei Nie¹, Xuying Xiang¹, Cheng Wen¹, Feng Zhang¹, Yuanpeng Xia¹, Yong Wang¹, Ling Mao¹

Affiliation

¹ Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, Hubei, China.

Abstract

Atherosclerosis (AS) is a long-standing cardiovascular and cerebrovascular disease. Its occurrence and development are related to the pathophysiology of lipids including cholesteryl ester (CE), cholesterol, triacylglycerol (TG), and phospholipid (PL). In this review, we focus on the roles and possible mechanisms of different lipid subcomponents in the process of AS, and provide new ideas for the prevention, diagnosis and treatment of AS.

Keywords: atherosclerosis plaque; lipid metabolism; lipid subcomponents.

Publication types

Review

Grants and funding

This work was supported by the National Natural Science Foundation of China (no. 81974182 and no. 82171325 to LM, no. 81771249 to YPX).