Translational control of papillomavirus mRNAs in the spotlight

Trends Cell Biol. 2024 Sep;34(9):703-706. doi: 10.1016/j.tcb.2024.07.001. Epub 2024 Jul 27.

Abstract

High-risk human papillomaviruses (HPVs) cause most cases of cervical cancer, a disease with an increasing impact worldwide. Recent studies have shown that the synthesis of viral oncoproteins is strongly subject to translational control. Thus, targeting the protein synthesis machinery might open novel avenues to develop innovative therapies aiming to improve patients' survival.

Keywords: cervical cancer; eIF4A; eIF4E; papillomavirus; translational control.

Publication types

  • Review

MeSH terms

  • Female
  • Gene Expression Regulation, Viral
  • Humans
  • Oncogene Proteins, Viral / genetics
  • Oncogene Proteins, Viral / metabolism
  • Papillomaviridae*
  • Papillomavirus Infections / virology
  • Protein Biosynthesis*
  • RNA, Messenger* / genetics
  • RNA, Messenger* / metabolism
  • RNA, Viral / genetics
  • RNA, Viral / metabolism
  • Uterine Cervical Neoplasms / genetics
  • Uterine Cervical Neoplasms / metabolism
  • Uterine Cervical Neoplasms / virology

Substances

  • RNA, Messenger
  • Oncogene Proteins, Viral
  • RNA, Viral