Living Donor Intestinal Transplantation

Pierpaolo Di Cocco; Alessandro Martinino; Federico Pinto; Benito Valdepenas 3rd; Mario Spaggiari; Ivo Tzvetanov; Enrico Benedetti

doi:10.1016/j.gtc.2023.12.005

Living Donor Intestinal Transplantation

Gastroenterol Clin North Am. 2024 Sep;53(3):441-452. doi: 10.1016/j.gtc.2023.12.005. Epub 2024 Jan 16.

Authors

Pierpaolo Di Cocco¹, Alessandro Martinino², Federico Pinto¹, Benito Valdepenas 3rd³, Mario Spaggiari¹, Ivo Tzvetanov¹, Enrico Benedetti¹

Affiliations

¹ Division of Transplantation, Department of Surgery, University of Illinois at Chicago, Chicago, IL, USA.
² Division of Transplantation, Department of Surgery, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: alessandro.martinino@gmail.com.
³ Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.

PMID: 39068005
DOI: 10.1016/j.gtc.2023.12.005

Abstract

This study explores intestinal transplantation (ITx) as a viable treatment option for intestinal failure (IF). Historical development, donor and recipient considerations, surgical techniques, immunosuppression, and outcomes, are reviewed with particular emphasis to the value of living donor ITx. The review highlights the evolution of ITx and emphasizes the ongoing need for patient-specific selection processes. In the realm of pediatric ITx, the article underlines the significance of early intervention to mitigate IF-related liver disease. Overall, it provides a comprehensive overview of this life-saving procedure.

Keywords: Immunosuppression; Intestinal transplantation; Living donor transplantation; Total parenteral nutrition (TPN).

Publication types

Review

MeSH terms

Humans
Intestinal Failure / surgery
Intestines* / transplantation
Living Donors*
Organ Transplantation / methods