Loss of ARID1A 'loops' in STING

Trends Immunol. 2024 Aug;45(8):568-570. doi: 10.1016/j.it.2024.07.001. Epub 2024 Jul 25.

Abstract

In a recent article, Maxwell et al. report that loss of tumor cell-specific AT-rich interaction domain 1A (ARID1A), a component of the chromatin remodeling SWI/SNF complex, triggers antitumor immunity via R-loop-mediated upregulation of the type-I interferon (IFN) pathway. These recent findings uncover a molecular mechanism underlying improved responses to immune checkpoint therapy (ICT) seen in patients harboring an ARID1A loss-of-function mutation.

Keywords: ARID1A; Interferon; R-loop; STING; anti-tumor immunity.

MeSH terms

  • Animals
  • Chromatin Assembly and Disassembly
  • DNA-Binding Proteins* / genetics
  • DNA-Binding Proteins* / metabolism
  • Humans
  • Interferon Type I / immunology
  • Interferon Type I / metabolism
  • Membrane Proteins* / genetics
  • Membrane Proteins* / metabolism
  • Mutation
  • Neoplasms* / genetics
  • Neoplasms* / immunology
  • Signal Transduction
  • Transcription Factors* / genetics
  • Transcription Factors* / metabolism

Substances

  • Transcription Factors
  • DNA-Binding Proteins
  • ARID1A protein, human
  • Membrane Proteins
  • STING1 protein, human
  • Interferon Type I