Keywords: TDD; TEL; amikacin; amphotericin B; antibiotic; antimicrobial; cefazolin; drug delivery; ecthyma gangrenosum; empiric treatment; epinephrine; infection; infiltration; injection; intralesional; leukemia cutis; lidocaine; necrosis; necrotic; necrotizing; oral dermatology; polymicrobial; skin infection; targeted; tumescent antibiotic delivery; tumescent delivery; tumescent drug delivery; tumescent epinephrine; tumescent epinephrine lidocaine; tumescent infiltration; tumescent injection; tumescent lidocaine; tumescent local anesthesia; ulcer.