Modular synthesis of 3,3-disubstituted oxindoles from nitrones and acrylic acids

Org Biomol Chem. 2024 Aug 7;22(31):6282-6287. doi: 10.1039/d4ob00964a.

Abstract

We developed a modular synthesis for 3,3-disubstituted oxindoles, utilising readily accessible nitrones and acrylic acids. This approach facilitates the preparation of a diverse array of oxindoles through the variation of the starting materials. We demonstrated the applicability of this method through a gram-scale reaction and a synthesis of esermethole.