Discovery and characterization of novel potent non-covalent small molecule inhibitors targeting papain-like protease from SARS-CoV-2

Affiliations

• ¹ Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
• ² Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, and University of Chinese Academy of Sciences, Beijing 100049, China.
• ³ School of Life Sciences and Biopharmaceuticals, Shenyang Pharmaceutical University, Shenyang 110016, China.
• ⁴ State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, and University of Chinese Academy of Sciences, Beijing 100049, China.
• ⁵ State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, China.
• ⁶ Lingang Laboratory, Shanghai 200031, China.
• ⁷ Hubei Jiangxia Laboratory, Wuhan 430200, China.
• ⁸ School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.