Association of tibial slope alterations with anterior cruciate ligament (ACL) injury and mucoid degeneration

Skeletal Radiol. 2025 Feb;54(2):325-334. doi: 10.1007/s00256-024-04744-x. Epub 2024 Jul 17.

Abstract

Objective: To compare radiographic measurements of lateral tibial slope (LTS), medial TS (MTS), and coronal TS (CTS) in MRI-defined intact, injured, and mucoid-degenerated native ACL knees and determine inter-reader reliability.

Materials and methods: Patient records from 2 years at tertiary care hospitals were reviewed for individuals aged 18-100 undergoing 3-Tesla knee MRI and radiographs. Two randomly selected cohorts, control, and pathologic ACLs on MRI with 86 patients each, were age, gender, and BMI-matched. A fellowship-trained musculoskeletal radiologist reevaluated curated images, characterizing ACL status. Two trained medical students independently collected clinical data and measured slopes on blinded radiographs. ICC, Cohen's kappa, and case-control matching were performed using SPSS statistical package, with ICC and ANOVA used for comparisons.

Results: Among 172 patients with 172 MRIs and radiographs, there were 86 controls and 86 ACL lesions. There were 108/172 (62.79%) males and 64/172 (37.21%) females. ICCs were 0.966 for MTS, 0.975 for LTS, and 0.978 for CTS. Mucoid degeneration patients had a higher BMI and were older than control (p < .05) or completely torn (p < .001) ACL patients. There was no difference in TS between normal and pathologic ACLs; however, LTS-MTS differences were larger with partial tears (2.5 ± 4.9) than normal ACLs by 4.5° (± 1.2, p < .001), complete tears by 4.5° (± 1.3, p < .001), and mucoid degeneration by 4.9° (± 1.5, p = .001).

Conclusion: Various TS measurements are reliable. LTS-MTS differences are associated with different ACL lesions compared to normal ACLs.

Keywords: ACL; Anterior cruciate ligament injury; Knee; Mucoid degeneration; Tibial slope.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anterior Cruciate Ligament Injuries* / diagnostic imaging
  • Case-Control Studies
  • Female
  • Humans
  • Magnetic Resonance Imaging* / methods
  • Male
  • Middle Aged
  • Reproducibility of Results
  • Retrospective Studies
  • Tibia* / diagnostic imaging
  • Tibia* / pathology
  • Young Adult