Autologous-Fibrin Induction: A Novel Approach for Sutureless Sclerotomy Closure in Pars Plana Vitrectomy

Curr Eye Res. 2024 Dec;49(12):1308-1312. doi: 10.1080/02713683.2024.2380441. Epub 2024 Jul 17.

Abstract

Purpose: This study presents a novel sutureless closure approach for sclerotomies following pars plana vitrectomy (PPV) and assesses its efficacy and safety.

Methods: A total of 142 eyes were included in the study. PPV procedures were performed using 23-gauge (23 G) or 25-gauge (25 G) systems. Preoperative characteristics, intraoperative findings, and postoperative outcomes were documented.

Results: The cohort included 80 males and 62 females (mean age: 60.4 ± 12 years), primarily undergoing surgery for retinal detachment (59%). Among the patients, 87% underwent 25 G PPV (35% three-port, 52% four-port), while 13% underwent 23 G PPV (12% three-port, 1% four-port). Gas tamponade was administered in all cases, with perfluoropropane used in 45.7% of instances, sulfur hexafluoride in 29.5%, and air in 24.6%. Spontaneous closure was observed in 9.4% (47 of 501) of sclerotomies, autologous-fibrin induction approach successfully closed 75.8% (380 of 501) of the sclerotomies (83.7% of leaking sclerotomies) and 14.7% (74 of 501) of sclerotomies needed sutures. Visual acuity improved postoperatively, and first-day hypotony rate was 6.3%. Importantly, no serious complications such as choroidal detachment or endophthalmitis were observed during the postoperative period.

Conclusion: The autologous-fibrin induction offers a simple, cost-efficient, and reliable approach for sutureless sclerotomy closure in PPV, with promising outcomes.

Keywords: Pars plana vitrectomy; hypotony; sclerotomy closure techniques; sutureless vitrectomy.

MeSH terms

  • Adult
  • Aged
  • Endotamponade*
  • Female
  • Fibrin Tissue Adhesive / therapeutic use
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Retinal Detachment / surgery
  • Retrospective Studies
  • Sclera* / surgery
  • Sclerostomy* / methods
  • Suture Techniques
  • Sutureless Surgical Procedures* / methods
  • Treatment Outcome
  • Visual Acuity* / physiology
  • Vitrectomy* / methods

Substances

  • Fibrin Tissue Adhesive