Pioneering the Photoactive Relevance of Quinazolinone-Fullereropyrrolidine Nanohybrids To Address Chemotherapeutic Resistance in Cancer

Devashish Sengupta; Debdulal Sharma; Ranjan Kumar Das; Prem Das; Madhumanti Halder; Pushkar Rai; Oishee Chakrabarti

doi:10.1021/acsmedchemlett.4c00187

Pioneering the Photoactive Relevance of Quinazolinone-Fullereropyrrolidine Nanohybrids To Address Chemotherapeutic Resistance in Cancer

ACS Med Chem Lett. 2024 Jun 24;15(7):1118-1126. doi: 10.1021/acsmedchemlett.4c00187. eCollection 2024 Jul 11.

Authors

Devashish Sengupta¹, Debdulal Sharma¹, Ranjan Kumar Das¹, Prem Das², Madhumanti Halder², Pushkar Rai¹, Oishee Chakrabarti^{2

3}

Affiliations

¹ Department of Chemistry, Assam University, Silchar-788011, Assam, India.
² Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata-700064, West Bengal, India.
³ Homi Bhabha National Institute, Mumbai-400094, Maharashtra, India.

PMID: 39015282
PMCID: PMC11247657 (available on 2025-07-11)
DOI: 10.1021/acsmedchemlett.4c00187

Abstract

This study investigates the impact of C₇₀ and C₆₀ fullerenes on quinazolinone, specifically in quinazolinone-fulleropyrrolidine nanohybrids. The nanohybrids Q ₃ C ₇₀ M and Q ₃ C ₆₀ M exhibit distinct spectral shifts and have significant photobiological antineoplastic properties. Q ₃ C ₆₀ M enhances apoptosis, while Q ₃ C ₇₀ M reduces Cyclin A levels and counteracts oncogenic effects by promoting cell differentiation. Q ₃ C ₇₀ M demonstrates heightened cytotoxicity by overcoming chemotherapy resistance by modulating BAX and BCL-2 levels. This innovative approach, distinguishing between C₇₀ and C₆₀, represents a novel contribution to the existing scientific literature.