The pros and confs of IL-18 activation

Danielle M Clancy; Julie Andries; Savvas N Savvides

doi:10.1016/j.immuni.2024.06.006

The pros and confs of IL-18 activation

Immunity. 2024 Jul 9;57(7):1445-1448. doi: 10.1016/j.immuni.2024.06.006.

Authors

Danielle M Clancy¹, Julie Andries¹, Savvas N Savvides²

Affiliations

¹ Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium; Unit for Structural Biology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
² Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium; Unit for Structural Biology, VIB-UGent Center for Inflammation Research, Ghent, Belgium. Electronic address: savvas.savvides@ugent.be.

PMID: 38986437
DOI: 10.1016/j.immuni.2024.06.006

Abstract

Interleukin-1 (IL-1) family cytokines are key immunological regulators that achieve their signaling prowess after post-translational proteolytic processing. In this issue of Immunity, Dong et al. reveal the structural consequences of this process on proinflammatory IL-18, demonstrating that pro-IL-18 and mature IL-18 are structurally distinct.

Publication types

Comment

MeSH terms

Animals
Humans
Interleukin-18* / immunology
Interleukin-18* / metabolism
Protein Processing, Post-Translational
Signal Transduction* / immunology

Substances

Interleukin-18