Background: Postoperative nausea and vomiting (PONV) is a significant problem following paediatric surgery, and volatile anaesthetics are an important cause of this phenomenon. BIS-guided anaesthesia, by reducing the consumption of anaesthetics, leads to a decrease in PONV in adult patients.
Study objective: Evaluate the role of BIS-guided anaesthesia in reducing the incidence of paediatric PONV.
Design: Prospective, randomized, double-blind study.
Setting: A single center study in university hospital in Czech republic, from June 2021 to November 2022.
Patients: A total of 163 children, aged 3-8 years with ASA I-II who underwent endoscopic adenoidectomy under general anaesthesia were included.
Interventions: In the intervention group, the depth of anaesthesia was maintained to values between 40 and 60 of BIS.
Main outcome measure: The primary outcome was the incidence of postoperative nausea and vomiting during 24 h after surgery.
Results: The use of BIS-guided anaesthesia led to a significant decrease in the incidence of nausea and vomiting compared to the control group [17% vs. 53%; RR (95%CI) 0.48 (0.27-0.86); p < 0.001and 16% vs. 34%; RR (95%CI) 0.33 (0.20-0.54); p = 0.01, respectively].
Conclusions: BIS-guided anaesthesia decreases the incidence of postoperative nausea and vomiting in children undergoing adenoidectomy.
Trial registration: Clinicaltrials.gov identifier: NCT04466579.
Keywords: BIS monitoring; Children; Postoperative nausea and vomiting; Postoperative pain.
© 2024. The Author(s).