Fe(III)-Triggered Radical Arylation of Arene Moieties from Cyclopropanols to Construct Dibenzocyclohepta/octanones: Synthesis of N-Acetylcolchinol- O-methyl ether

Org Lett. 2024 Aug 23;26(33):6950-6954. doi: 10.1021/acs.orglett.4c02047. Epub 2024 Jul 9.

Abstract

Tricyclic 6-7-6 and 6-8-6 carbon ring systems are present in numerous biologically active natural molecules. However, simple and efficient synthetic approaches to these scaffolds remain challenging. Herein, we report a versatile strategy for constructing these ring systems via Fe(NO3)3-triggered radical arylation of arenes starting from cyclopropanols. This synthetic utility has been demonstrated in the synthesis of the natural product N-acetylcolchinol-O-methyl ether.