Selective binding of c-MYC G-quadruplex caged in a dsDNA by a hemopeptide

Leen Massalha; Adiel Richter Levin; Nurit Adiram-Filiba; Eyal Golub

doi:10.1039/d4cc01389a

Selective binding of c-MYC G-quadruplex caged in a dsDNA by a hemopeptide

Chem Commun (Camb). 2024 Jul 23;60(60):7769-7772. doi: 10.1039/d4cc01389a.

Authors

Leen Massalha¹, Adiel Richter Levin¹, Nurit Adiram-Filiba¹, Eyal Golub¹

Affiliation

¹ Department of Chemistry, Faculty of Exact Sciences and Institute of Nanotechnology and Advanced Materials, Bar Ilan University, 5290002, Israel. Eyal.Golub@biu.ac.il.

PMID: 38973676
DOI: 10.1039/d4cc01389a

Abstract

The microperoxidase-11 hemopeptide exhibits configuration-dependent selectivity for guanine-quadruplexes by specifically uncaging c-MYC guanine-quadruplexes from a duplex DNA.

MeSH terms

DNA* / chemistry
DNA* / metabolism
G-Quadruplexes*
Humans
Peptides / chemistry
Peptides / metabolism
Peroxidases / chemistry
Peroxidases / metabolism
Proto-Oncogene Proteins c-myc / chemistry
Proto-Oncogene Proteins c-myc / metabolism

Substances

DNA
Peptides
Proto-Oncogene Proteins c-myc
Peroxidases