The emerging role of the exosomal proteins in neuroblastoma

Front Oncol. 2024 Jun 19:14:1414063. doi: 10.3389/fonc.2024.1414063. eCollection 2024.

Abstract

Exosomes are a subclass of extracellular vesicles shown to promote the cancer growth and support metastatic progression. The proteomic analysis of neuroblastoma-derived exosomes has revealed proteins involved in cell migration, proliferation, metastasis, and in the modulation of tumor microenvironment - thus contributing to the tumor development and an aggressive metastatic phenotype. This review gives an overview of the current understanding of the exosomal proteins in neuroblastoma and of their potential as diagnostic/prognostic biomarker of disease and therapeutics.

Keywords: biomarkers; exosomal proteins; exosomes; metastatic progression; neuroblastoma-derived exosomes; proteomic analysis; tumor microenvironment.

Publication types

  • Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by research grant from the Barnekreftforeningen (Project number: 240002). The publication charges for this article have been funded by a grant from the publication fund of UiT - The Arctic University of Norway. The funding organizations have no role in the design of the study, analysis, and interpretation of the data and in writing the manuscript.