A nose for tau

Sci Transl Med. 2024 Jul 3;16(754):eadq6489. doi: 10.1126/scitranslmed.adq6489. Epub 2024 Jul 3.

Authors

Soraya Meftah^{1

2}, Claire S Durrant^{1

2}, Tara L Spires-Jones^{1

2}

Affiliations

¹ UK Dementia Research Institute at University of Edinburgh, Edinburgh EH8 9JZ, UK.
² Centre for Discovery Brain Sciences, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh EH8 9JZ, UK.

PMID: 38959325
DOI: 10.1126/scitranslmed.adq6489

Abstract

Nasal delivery of an oligomeric tau antibody loaded into micelles reduces pathology and ameliorates cognition in a mouse model of tauopathy.

Publication types

Review

MeSH terms

Administration, Intranasal*
Animals
Antibodies / immunology
Antibodies / therapeutic use
Disease Models, Animal
Humans
Mice
Micelles
Nose
Tauopathies* / metabolism
Tauopathies* / pathology
tau Proteins* / metabolism

Substances

tau Proteins
Micelles
Antibodies