An Anti-CD138-Targeted Interferon-Alpha Has Broad Efficacy in Solid Tumors Through Direct Tumor Cell Killing and Intratumoral Immune Modulation

J Interferon Cytokine Res. 2024 Sep;44(9):414-423. doi: 10.1089/jir.2024.0099. Epub 2024 Jul 1.

Authors

Tahmineh Safaie¹, Kham R Trinh¹, Alex Vasuthasawat¹, Sherie L Morrison², David R Stover¹

Affiliations

¹ Nammi Therapeutics, Los Angeles, California, USA.
² Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA.

PMID: 38949948
DOI: 10.1089/jir.2024.0099

No abstract available

Keywords: anti-CD138; antibody-targeted immunotherapy; interferon; mouse syngeneic models; solid tumors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Humans
Interferon-alpha* / immunology
Interferon-alpha* / metabolism
Neoplasms* / drug therapy
Neoplasms* / immunology

Substances

Interferon-alpha