Meeting report: DMPK optimisation strategies and quantitative translational PKPD frameworks to predict human PK and efficacious dose of targeted protein degraders
Xenobiotica
.
2024 Sep;54(9):776-780.
doi: 10.1080/00498254.2024.2369787.
Epub 2024 Jul 12.
Authors
Caroline Rynn
1
,
Heide Marika Duevel
2
Affiliations
1
Department of Pharmaceutical Sciences, Roche Products Ltd, Welwyn, UK.
2
Discovery & Development Technologies, Merck KGaA, Darmstadt, Germany.
PMID:
38934475
DOI:
10.1080/00498254.2024.2369787
No abstract available
Keywords:
ADME; DMPK; PBPK; PKPD; POI; PROTAC; Protein Degraders; TPD; modelling and simulation.