Computer-aided design of a fluorescent MAT2A inhibitor for visualized cancer synthetic lethality

Ziwei Wang; Wenting Zhou; Xiao Chen; Yuxuan Wu; Yihan Huang; Feiyang Li; Zhiwei Gong; Juan Xu; Huan He; Silong Zhang

doi:10.1016/j.bioorg.2024.107582

Computer-aided design of a fluorescent MAT2A inhibitor for visualized cancer synthetic lethality

Bioorg Chem. 2024 Sep:150:107582. doi: 10.1016/j.bioorg.2024.107582. Epub 2024 Jun 20.

Authors

Ziwei Wang¹, Wenting Zhou², Xiao Chen³, Yuxuan Wu³, Yihan Huang³, Feiyang Li³, Zhiwei Gong², Juan Xu⁴, Huan He⁵, Silong Zhang⁶

Affiliations

¹ Key Laboratory of Coal Conversion and New Carbon Materials of Hubei Province, College of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, PR China; Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), Guizhou Engineering Laboratory for Synthetic Drugs, School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, PR China.
² Key Laboratory of Coal Conversion and New Carbon Materials of Hubei Province, College of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, PR China.
³ Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), Guizhou Engineering Laboratory for Synthetic Drugs, School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, PR China.
⁴ College of Chemistry and Chemical Engineering, Hubei Polytechnic University, Huangshi 435003, PR China. Electronic address: xujuan@whu.edu.cn.
⁵ Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), Guizhou Engineering Laboratory for Synthetic Drugs, School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, PR China. Electronic address: ivy@whu.edu.cn.
⁶ Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), Guizhou Engineering Laboratory for Synthetic Drugs, School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, PR China. Electronic address: silongzhang@whu.edu.cn.

PMID: 38924884
DOI: 10.1016/j.bioorg.2024.107582

No abstract available

MeSH terms

Antineoplastic Agents* / chemical synthesis
Antineoplastic Agents* / chemistry
Antineoplastic Agents* / pharmacology
Computer-Aided Design
Dose-Response Relationship, Drug
Drug Design
Drug Screening Assays, Antitumor
Enzyme Inhibitors / chemical synthesis
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology
Fluorescent Dyes / chemical synthesis
Fluorescent Dyes / chemistry
Fluorescent Dyes / pharmacology
Histone-Lysine N-Methyltransferase / antagonists & inhibitors
Histone-Lysine N-Methyltransferase / metabolism
Humans
Methionine Adenosyltransferase / antagonists & inhibitors
Methionine Adenosyltransferase / chemistry
Methionine Adenosyltransferase / metabolism
Molecular Structure
Structure-Activity Relationship
Synthetic Lethal Mutations

Substances

Antineoplastic Agents
Enzyme Inhibitors
Fluorescent Dyes
Histone-Lysine N-Methyltransferase
Methionine Adenosyltransferase