Ovarian sclerosing stromal tumor mimicking malignancy: case series and literature review

Arch Gynecol Obstet. 2024 Aug;310(2):1171-1177. doi: 10.1007/s00404-024-07520-3. Epub 2024 Jun 24.

Abstract

Background: Sclerosing stromal tumors (SST) are rare ovarian neoplasms that often appear as solid unilateral tumors of the ovary with no specific clinical or radiological presentation. The definitive treatment is surgical removal.

Case presentation: Our article presents four cases of female patients with sclerosing stromal ovarian tumor with clinical characteristics mimicking malignant ovarian lesions. Interestingly, two of our cases had elevated levels of inhibin B. All patients were treated with surgery (oophorectomy) and had no disease recurrence.

Conclusion: Tumors' macroscopic features are usually non-specific and often suggestive of possible malignancy, therefore diagnosis is always based on histopathological report.

Keywords: Adolescence; Fertility-sparing surgery; Ovarian cancer; Postmenopausal period; Sclerosing stromal tumor.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Diagnosis, Differential
  • Female
  • Humans
  • Inhibins / blood
  • Ovarian Neoplasms* / diagnosis
  • Ovarian Neoplasms* / pathology
  • Ovarian Neoplasms* / surgery
  • Ovariectomy
  • Sex Cord-Gonadal Stromal Tumors / diagnosis
  • Sex Cord-Gonadal Stromal Tumors / pathology
  • Sex Cord-Gonadal Stromal Tumors / surgery

Substances

  • Inhibins