Extensive Spinal Epidural Abscess: A Systematic Review of Risk Factors, Clinical Presentation, and Management with a Case Illustration

World Neurosurg. 2024 Sep:189:273-284. doi: 10.1016/j.wneu.2024.06.073. Epub 2024 Jun 19.

Abstract

Background: Extensive spinal epidural abscess (ESEA) is a rare clinical entity subject to delayed diagnosis, which can be explained by the extension of the epidural collection, thereby delaying the mass effect responsible for its clinical manifestations.

Methods: We report a rare case of an extensive C7-T10 epidural abscess in a 54-year-old man treated with antibiotics, laminectomy, and abscess drainage. In addition, we conducted a systematic literature search according to the "Preferred Reporting Items for Systematic Reviews" guidelines. Relevant studies (1980-2023) reporting patients with ESEA were identified from PubMed databases.

Results: A total of 48 studies reporting 55 patients were included in this study with a mean age of 55.7 ± 14.6 years with a male predominance of 61.8% (n = 34). The median duration of follow-up was 38 months (21.5-64.3). The mortality rate of ESEA was 1.8% for a 21.8% morbidity rate with 76.4% (n = 42) reported to have been improved after surgery.

Conclusions: Both single and multilevel laminectomy with abscess drainage for ESEA leads to patient recovery from this devastating condition. Evaluation of the outcome with data on time-to-Nadir and Nadir-to-surgery is needed to codify ESEA management.

Keywords: Case report; Epidural abscess; Extensive; Spinal; Systematic review.

Publication types

  • Systematic Review
  • Case Reports
  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Cervical Vertebrae / surgery
  • Drainage / methods
  • Epidural Abscess* / surgery
  • Humans
  • Laminectomy*
  • Male
  • Middle Aged
  • Risk Factors
  • Thoracic Vertebrae / diagnostic imaging
  • Thoracic Vertebrae / surgery

Substances

  • Anti-Bacterial Agents