Understanding the Role of Endothelial Cells in Glioblastoma: Mechanisms and Novel Treatments

Gabrielle Hovis; Neha Chandra; Nidhi Kejriwal; Kaleb Jia-Yi Hsieh; Alison Chu; Isaac Yang; Madhuri Wadehra

doi:10.3390/ijms25116118

Understanding the Role of Endothelial Cells in Glioblastoma: Mechanisms and Novel Treatments

Int J Mol Sci. 2024 Jun 1;25(11):6118. doi: 10.3390/ijms25116118.

Authors

Gabrielle Hovis¹, Neha Chandra², Nidhi Kejriwal², Kaleb Jia-Yi Hsieh², Alison Chu³, Isaac Yang^{1

4

5

6

7}, Madhuri Wadehra^{2

7}

Affiliations

¹ Department of Neurosurgery, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA.
² Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA.
³ Division of Neonatology and Developmental Biology, Department of Pediatrics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA.
⁴ Department of Radiation Oncology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA.
⁵ Department of Head and Neck Surgery, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA.
⁶ Lundquist Institute, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
⁷ Jonsson Comprehensive Cancer Center, University of California-Los Angeles, Los Angeles, CA 90095, USA.

Abstract

Glioblastoma is a highly aggressive neoplasm and the most common primary malignant brain tumor. Endothelial tissue plays a critical role in glioblastoma growth and progression, facilitating angiogenesis, cellular communication, and tumorigenesis. In this review, we present an up-to-date and comprehensive summary of the role of endothelial cells in glioblastomas, along with an overview of recent developments in glioblastoma therapies and tumor endothelial marker identification.

Keywords: angiogenesis; endothelium; glioblastoma; tumor marker.

Publication types

Review

MeSH terms

Animals
Biomarkers, Tumor / metabolism
Brain Neoplasms* / metabolism
Brain Neoplasms* / pathology
Brain Neoplasms* / therapy
Endothelial Cells* / metabolism
Endothelial Cells* / pathology
Glioblastoma* / metabolism
Glioblastoma* / pathology
Glioblastoma* / therapy
Humans
Neovascularization, Pathologic*

Substances

Biomarkers, Tumor

Grants and funding

Isaac Yang is supported by the UCLA Visionary Ball Fund Grant, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research UCLA Scholars in Translational Medicine Program Award, Jason Dessel Memorial Seed Grant, UCLA Honberger Endowment Brain Tumor Research Seed Grant, and Stop Cancer (US) Development Award. The sponsors had no role in the design or conduct of this research. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.