The Biological Role of Platelet Derivatives in Regenerative Aesthetics

Int J Mol Sci. 2024 May 21;25(11):5604. doi: 10.3390/ijms25115604.

Abstract

Bioproducts derived from platelets have been extensively used across various medical fields, with a recent notable surge in their application in dermatology and aesthetic procedures. These products, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), play crucial roles in inducing blood vessel proliferation through growth factors derived from peripheral blood. PRP and PRF, in particular, facilitate fibrin polymerization, creating a robust structure that serves as a reservoir for numerous growth factors. These factors contribute to tissue regeneration by promoting cell proliferation, differentiation, and migration and collagen/elastin production. Aesthetic medicine harnesses these effects for diverse purposes, including hair restoration, scar treatment, striae management, and wound healing. Furthermore, these biological products can act as adjuvants with other treatment modalities, such as laser therapy, radiofrequency, and microneedling. This review synthesizes the existing evidence, offering insights into the applications and benefits of biological products in aesthetic medicine.

Keywords: aesthetic medicine; growth factors; platelet-rich fibrin; platelet-rich plasma; tissue regeneration.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood Platelets / metabolism
  • Cell Proliferation
  • Humans
  • Platelet-Rich Fibrin* / metabolism
  • Platelet-Rich Plasma* / chemistry
  • Platelet-Rich Plasma* / metabolism
  • Regeneration
  • Regenerative Medicine* / methods
  • Wound Healing

Grants and funding

This research received no external funding.