A Prostatic Intraepithelial Neoplasia-Dependent p27Kip1 Checkpoint Induces Senescence and Inhibits Cell Proliferation and Cancer Progression

MeSH terms

• Animals
• Cell Cycle Checkpoints / drug effects
• Cell Line, Tumor
• Cell Proliferation* / drug effects
• Cellular Senescence* / drug effects
• Cyclin-Dependent Kinase Inhibitor p27* / genetics
• Cyclin-Dependent Kinase Inhibitor p27* / metabolism
• Disease Progression
• Humans
• Male
• Mice
• Prostatic Intraepithelial Neoplasia* / genetics
• Prostatic Intraepithelial Neoplasia* / metabolism
• Prostatic Intraepithelial Neoplasia* / pathology
• Prostatic Neoplasms* / drug therapy
• Prostatic Neoplasms* / genetics
• Prostatic Neoplasms* / metabolism
• Prostatic Neoplasms* / pathology