H2Se-evolving bio-heterojunctions promote cutaneous regeneration in infected wounds by inhibiting excessive cellular senescence

Fan Yang; Rui Shu; Wenyu Dai; Bin Li; Chuang Liu; Hang Yang; Hannah M Johnson; Sheng Yu; Ding Bai; Weizhong Yang; Yi Deng

doi:10.1016/j.biomaterials.2024.122659

H₂Se-evolving bio-heterojunctions promote cutaneous regeneration in infected wounds by inhibiting excessive cellular senescence

Biomaterials. 2024 Dec:311:122659. doi: 10.1016/j.biomaterials.2024.122659. Epub 2024 Jun 7.

Authors

Fan Yang¹, Rui Shu², Wenyu Dai¹, Bin Li¹, Chuang Liu³, Hang Yang³, Hannah M Johnson⁴, Sheng Yu⁴, Ding Bai¹, Weizhong Yang⁵, Yi Deng⁶

Affiliations

¹ State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, College of Biomedical Engineering, School of Chemical Engineering, Sichuan University, Chengdu, China; Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
² State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, College of Biomedical Engineering, School of Chemical Engineering, Sichuan University, Chengdu, China; Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
³ State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, College of Biomedical Engineering, School of Chemical Engineering, Sichuan University, Chengdu, China.
⁴ Department of Chemistry, Washington State University, Washington, USA.
⁵ State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, College of Biomedical Engineering, School of Chemical Engineering, Sichuan University, Chengdu, China. Electronic address: ywz@scu.edu.cn.
⁶ State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, College of Biomedical Engineering, School of Chemical Engineering, Sichuan University, Chengdu, China; State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, China; Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, China. Electronic address: dengyibandeng@scu.edu.cn.

PMID: 38861831
DOI: 10.1016/j.biomaterials.2024.122659

Abstract

Pathogenic infection leads to excessive senescent cell accumulation and stagnation of wound healing. To address these issues, we devise and develop a hydrogen selenide (H₂Se)-evolving bio-heterojunction (bio-HJ) composed of graphene oxide (GO) and FeSe₂ to deracinate bacterial infection, suppress cellular senescence and remedy recalcitrant infected wounds. Excited by near-infrared (NIR) laser, the bio-HJ exerts desired photothermal and photodynamic effects, resulting in rapid disinfection. The crafted bio-HJ could also evolve gaseous H₂Se to inhibit cellular senescence and dampen inflammation. Mechanism studies reveal the anti-senescence effects of H₂Se-evolving bio-HJ are mediated by selenium pathway and glutathione peroxidase 1 (GPX1). More critically, in vivo experiments authenticate that the H₂Se-evolving bio-HJ could inhibit cellular senescence and potentiate wound regeneration in rats. As envisioned, our work not only furnishes the novel gasotransmitter-delivering bio-HJ for chronic infected wounds, but also gets insight into the development of anti-senescence biomaterials.

Keywords: Heterojunction; Hydrogen selenide; Senescence; Wound healing.

MeSH terms

Animals
Cellular Senescence* / drug effects
Graphite* / chemistry
Graphite* / pharmacology
Humans
Male
Mice
Rats
Rats, Sprague-Dawley
Regeneration / drug effects
Skin / drug effects
Skin / pathology
Wound Healing* / drug effects
Wound Infection / drug therapy
Wound Infection / pathology

Substances

Graphite
graphene oxide