Imaging Neurotransmitters with Small-Molecule Fluorescent Probes

Angew Chem Int Ed Engl. 2024 Aug 19;63(34):e202406401. doi: 10.1002/anie.202406401. Epub 2024 Jul 12.

Abstract

Neurotransmitters play a crucial role in regulating communication between neurons within the brain and central nervous system. Thus, imaging neurotransmitters has become a high priority in neuroscience. This minireview focuses on recent advancements in the development of fluorescent small-molecule fluorescent probes for neurotransmitter imaging and applications of these probes in neuroscience. Innovative approaches for probe design are highlighted as well as attributes which are necessary for practical utility, with a view to inspiring new probe development capable of visualizing neurotransmitters.

Publication types

  • Review

MeSH terms

  • Animals
  • Fluorescent Dyes* / chemistry
  • Humans
  • Neurotransmitter Agents* / analysis
  • Optical Imaging
  • Small Molecule Libraries / chemistry

Substances

  • Fluorescent Dyes
  • Neurotransmitter Agents
  • Small Molecule Libraries