The association of red and processed meat with gestational diabetes mellitus: Results from 2 Canadian birth cohort studies

PLoS One. 2024 May 30;19(5):e0302208. doi: 10.1371/journal.pone.0302208. eCollection 2024.

Abstract

Objective: Red and processed meat is considered risk factors of gestational diabetes mellitus (GDM), but the evidence is inconclusive. We aimed to examine the association between red and processed meat intake and odds of GDM among South Asian and White European women living in Canada.

Methods: This is a cross-sectional analysis of pregnant women from two birth cohorts: SouTh Asian biRth cohorT (START; n = 976) and Family Atherosclerosis Monitoring In earLY life (FAMILY; n = 581). Dietary intake was assessed using a validated 169-item semi-quantitative food-frequency questionnaire (FFQ). Multivariate logistic regression models were used to examine the associations between gestational diabetes and: 1) total red and processed meat; 2) unprocessed red meat; 3) processed meat and GDM after adjustment for potential confounders.

Results: There were 241 GDM cases in START and 91 in FAMILY. The median total red and processed meat intake were 1.5 g/d (START) and 52.8 g/d (FAMILY). In START, the multivariable-adjusted odds ratio (OR) showed neither lower nor higher intakes of unprocessed red meat (p-trend = 0.68), processed meat (p-trend = 0.90), or total red and processed meat (p-trend = 0.44), were associated with increased odds of GDM, when compared with medium intake. Similar results were observed in FAMILY except for processed meat intake [OR = 0.94 (95% CI 0.47-1.91), for medium versus low and OR = 1.51 (95% CI 0.77-2.29) for medium versus high; p-trend = 0.18] after adjusting for additional dietary factors such as the diet quality score, total fiber, saturated fat and glycemic load.

Conclusion: Medium compared with low or high red and processed meat intake is not associated with GDM in White Europeans and South Asians living in Canada.

MeSH terms

  • Adult
  • Canada / epidemiology
  • Cohort Studies
  • Cross-Sectional Studies
  • Diabetes, Gestational* / epidemiology
  • Diabetes, Gestational* / etiology
  • Diet / adverse effects
  • Female
  • Humans
  • Meat Products / adverse effects
  • Pregnancy
  • Red Meat / adverse effects
  • Risk Factors

Grants and funding

START - Canadian Institutes of Health Research (Grant INC-109205; https://cihr-irsc.gc.ca/e/193.html), and the Heart and Stroke Foundation of Canada: (Grant NA 7283; https://www.heartandstroke.ca/): S S Anand, K Morrison and K K Teo START has not received funding/assistance from a commercial organization. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.