Alternatively spliced ELAVL3 cryptic exon 4a causes ELAVL3 downregulation in ALS TDP-43 proteinopathy

Acta Neuropathol. 2024 May 30;147(1):93. doi: 10.1007/s00401-024-02732-y.

Authors

Isabel Costantino^{1

2

3}, Alex Meng¹, John Ravits⁴

Affiliations

¹ Department of Neurosciences, ALS Translational Research, University of California San Diego, La Jolla, CA, USA.
² Neurosciences Graduate Program, University of California San Diego, La Jolla, CA, USA.
³ Medical Scientist Training Program, School of Medicine, University of California San Diego, La Jolla, CA, USA.
⁴ Department of Neurosciences, ALS Translational Research, University of California San Diego, La Jolla, CA, USA. jravits@ucsd.edu.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Alternative Splicing* / genetics
Amyotrophic Lateral Sclerosis* / genetics
Amyotrophic Lateral Sclerosis* / metabolism
Amyotrophic Lateral Sclerosis* / pathology
DNA-Binding Proteins
Down-Regulation*
Exons* / genetics
Female
Humans
Male
Middle Aged
TDP-43 Proteinopathies / genetics
TDP-43 Proteinopathies / metabolism
TDP-43 Proteinopathies / pathology

Substances

TARDBP protein, human
DNA-Binding Proteins

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