Late-onset NPM1 mutation in a MYC-amplified relapsed/refractory acute myeloid leukemia patient treated with gemtuzumab ozogamicin and glasdegib

Sonia Jaramillo; Michael Scherer; Chelsea Szu-Tu; Sergi Beneyto-Calabuig; Carsten Müller-Tidow; Richard F Schlenk; Michael Hundemer; Lars Velten; Caroline Pabst

doi:10.3324/haematol.2023.284922

Late-onset NPM1 mutation in a MYC-amplified relapsed/refractory acute myeloid leukemia patient treated with gemtuzumab ozogamicin and glasdegib

Haematologica. 2024 Nov 1;109(11):3811-3815. doi: 10.3324/haematol.2023.284922.

Authors

Sonia Jaramillo¹, Michael Scherer², Chelsea Szu-Tu², Sergi Beneyto-Calabuig², Carsten Müller-Tidow³, Richard F Schlenk⁴, Michael Hundemer¹, Lars Velten⁵, Caroline Pabst⁶

Affiliations

¹ Department of Internal Medicine V, Heidelberg University Hospital.
² Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona.
³ Department of Internal Medicine V, Heidelberg University Hospital, Germany; Molecular Medicine Partnership Unit (MMPU), University of Heidelberg and European Molecular Biology Laboratory, Heidelberg.
⁴ Department of Internal Medicine V, Heidelberg University Hospital, Germany; NCT-Trial Center, National Center of Tumor Diseases, Heidelberg University Hospital and German Cancer Research Center.
⁵ Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona.
⁶ Department of Internal Medicine V, Heidelberg University Hospital, Germany; Molecular Medicine Partnership Unit (MMPU), University of Heidelberg and European Molecular Biology Laboratory, Heidelberg. Caroline.Pabst@med.uni-heidelberg.de.

No abstract available

Grants and funding

Funding: This research was funded by the José Carreras Leukaemia Foundation (DJCLS 01SP/(12)2022). CP is supported by a Max-Eder grant of German Cancer Aid (70114435). The authors gratefully acknowledge the data storage service SDS@hd supported by the Ministry of Science, Research and the Arts Baden-Württemberg (MWK) and the German Research Foundation (DFG) through grant INST 35/1314-1 FUGG and INST 35/1503-1 FUGG. MS was supported through the Walter Benjamin Fellowship funded by Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – 493935791.