Pulmonary Tumor Embolism due to Oropharyngeal Carcinoma Diagnosed by a Transbronchial Lung Biopsy

Intern Med. 2025 Jan 15;64(2):267-271. doi: 10.2169/internalmedicine.3596-24. Epub 2024 May 30.

Abstract

Pulmonary tumor embolisms (PTEs) are primarily caused by adenocarcinoma. However, only a few cases of oropharyngeal carcinoma have been reported. We herein report a 47-year-old man who presented with a fever, cough, and dyspnea 6 months after treatment for stage II oropharyngeal carcinoma. Chest computed tomography revealed centrilobular granular and nodular shadows and subpleural consolidation. A transbronchial lung biopsy revealed a mass of squamous tumor cells forming emboli in the small vessels, resulting in the diagnosis of PTE due to oropharyngeal carcinoma. Therefore, PTE should be considered for patients with a history of hypoxia.

Keywords: oropharyngeal carcinoma; pulmonary tumor embolism; transbronchial lung biopsy.

Publication types

  • Case Reports

MeSH terms

  • Biopsy / methods
  • Carcinoma, Squamous Cell / complications
  • Carcinoma, Squamous Cell / diagnosis
  • Carcinoma, Squamous Cell / pathology
  • Humans
  • Lung / diagnostic imaging
  • Lung / pathology
  • Lung Neoplasms / complications
  • Lung Neoplasms / diagnosis
  • Lung Neoplasms / pathology
  • Male
  • Middle Aged
  • Neoplastic Cells, Circulating / pathology
  • Oropharyngeal Neoplasms* / complications
  • Oropharyngeal Neoplasms* / diagnosis
  • Oropharyngeal Neoplasms* / pathology
  • Pulmonary Embolism* / diagnosis
  • Pulmonary Embolism* / diagnostic imaging
  • Pulmonary Embolism* / etiology
  • Tomography, X-Ray Computed