ST88 ceftazidime-resistant Stenotrophomonas maltophilia is present in the saliva and gingival crevicular fluid of patients with periodontitis and AIDS from São Paulo State, Brazil

Braz J Microbiol. 2024 Sep;55(3):3031-3035. doi: 10.1007/s42770-024-01395-x. Epub 2024 May 29.

Abstract

Stenotrophomonas maltophilia (S. maltophilia) is an intrinsically drug-resistant and biofilm-forming bacteria causing infections in immunocompromised humans. This study reports the isolation of five S. maltophilia strains from saliva and gingival crevicular fluid (GCF) of AIDS patients with periodontitis in São Paulo, Brazil, showing resistance to ceftazidime, strong biofilm formation capacity and a close genetic relationship. The presence of S. maltophilia strains in saliva and CGF of patients with AIDS and periodontitis is a concern for the presence and persistence of intrinsically resistant bacteria in the oral environment, enhancing the risk for the development of severe infections in immunocompromised patients.

Keywords: Stenotrophomonas maltophilia; Antibiotic resistance; HIV; Molecular typing; biofilms.

Publication types

  • Letter

MeSH terms

  • Acquired Immunodeficiency Syndrome* / microbiology
  • Adult
  • Anti-Bacterial Agents* / pharmacology
  • Biofilms* / drug effects
  • Biofilms* / growth & development
  • Brazil
  • Ceftazidime* / pharmacology
  • Drug Resistance, Bacterial
  • Female
  • Gingival Crevicular Fluid* / chemistry
  • Gingival Crevicular Fluid* / microbiology
  • Gram-Negative Bacterial Infections* / microbiology
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Periodontitis* / microbiology
  • Saliva* / microbiology
  • Stenotrophomonas maltophilia* / drug effects
  • Stenotrophomonas maltophilia* / genetics
  • Stenotrophomonas maltophilia* / isolation & purification

Substances

  • Ceftazidime
  • Anti-Bacterial Agents