Genetic damage among children living in agricultural areas in the North of Colombia

An Acad Bras Cienc. 2024 Apr 22;96(1):e20221111. doi: 10.1590/0001-3765202420221111. eCollection 2024.

Abstract

In recent years, the use of pesticides has increased considerably for pest control and to improve agricultural production. The rural areas of several municipalities of department of Cordoba, north of Colombia, are highly dependent on agriculture. In this study, a questionnaire and field observations about pesticide use and genotoxic damage through the comet assay in peripheral blood lymphocytes of children who live near crop fields was evaluated. Damage Index for Comet Assay (DICA) of five children populations exposed to pesticides (mean of 94.73±53.95 for the municipality of Monteria, the higher damage in this study) were significantly Higher than control children population (mean of 7.56±7.39). Results showed the damage index in children exposed group was higher than in the control group. An inadequate management of pesticides, as well as incorrect disposal of toxic wastes was observed in the study zone.

MeSH terms

  • Adolescent
  • Agriculture*
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Colombia
  • Comet Assay*
  • DNA Damage* / drug effects
  • Environmental Exposure* / adverse effects
  • Female
  • Humans
  • Lymphocytes / drug effects
  • Male
  • Pesticides* / adverse effects
  • Pesticides* / toxicity
  • Rural Population
  • Surveys and Questionnaires

Substances

  • Pesticides