Heart Failure With Reduced Ejection Fraction in a Patient With Erdheim-Chester Disease on Dabrafenib

JACC Case Rep. 2024 May 18;29(12):102374. doi: 10.1016/j.jaccas.2024.102374. eCollection 2024 Jun 19.

Abstract

A 54-year-old woman with a diagnosis of Erdheim-Chester disease under therapy with dabrafenib presents with clinical signs of heart failure. After discontinuing the offending medication and initiating guideline-directed medical therapy for heart failure with reduced ejection fraction, the clinical picture improved.

Keywords: Erdheim-Chester disease; aortitis; cardiorenal syndrome; dabrafenib; heart failure with reduced ejection fraction.

Publication types

  • Case Reports